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Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - HC067047 Hydrochloride(883031-03-6 free base)

HC067047 Hydrochloride(883031-03-6 free base)

CAS No. 1481646-76-7

HC067047 Hydrochloride(883031-03-6 free base)( —— )

Catalog No. M23636 CAS No. 1481646-76-7

HC-067047 hydrochloride is a potent and selective TRPV4 antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HC067047 Hydrochloride(883031-03-6 free base)
  • Note
    Research use only, not for human use.
  • Brief Description
    HC-067047 hydrochloride is a potent and selective TRPV4 antagonist.
  • Description
    HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 486 nM, 133nM, and 17 nM, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPV4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1481646-76-7
  • Formula Weight
    507.98
  • Molecular Formula
    C26H29ClF3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=C(C)N(CCCN2CCOCC2)C(C3=CC=CC=C3)=C1)NC4=CC=CC(C(F)(F)F)=C4.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xing Y , Ming J , Liu T , et al. Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment[J]. Yonsei medical journal, 2018, 59(9).
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